Amy G. McNeilage, Alison Sim, Suzanne Nielsen, Bridin Murnion, Claire E. Ashton-James
Highlights
- Gabapentinoids have been misused to potentiate, withdraw from or substitute opioids.
- Gabapentinoids are sometimes used recreationally for euphoria and relaxation.
- Some describe misusing gabapentinoids to cope with pain, distress, and insomnia.
- There are reports of serious psychiatric symptoms when discontinuing pregabalin.
- Harms including overdose are generally reported in the context of poly-drug use.
Background
Gabapentinoids are among the most widely prescribed pain medications worldwide. However, there is growing evidence of harms associated with their use. The aim of this study was to systematically review and synthesise qualitative research exploring lived experiences of gabapentinoid (pregabalin and/or gabapentin) misuse and symptoms of dependence.
Conclusion
This review provides rich qualitative insights into the potential motives for gabapentinoid misuse as well as the diverse lived experiences of dependence symptomatology. Considering the increasing prescribing of these medications globally, and the potential for public health challenges resulting from misuse, the findings of this review can be used to develop more effective harm reduction strategies.
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